"People of Earth" centers on skeptical journalist Ozzie Graham (Cenac), who investigates a support group to write about the member's supposed alien encounters. The more he digs into their oddball claims, the more he realizes a semblance of truth to their stories and possibly even signs that point to his own alien abduction. The onetime outsider now finds himself a part of this eclectic group of misfits, all the while struggling with the idea of knowing that life could exist beyond our world.

Gina Morrison (Ana Gasteyer), a part-time therapist, runs the support group. Her regulars include Kelly Grady (Alice Wetterlund), an obliviously attractive goofball; Gerry Johnson (Luka Jones), an amiable social dropout, tollbooth worker and enthusiastic expert on all things alien; Richard Shenk (Brian Huskey), a tech company employee convinced his wife is held captive by aliens; Margaret Flood (Nancy Lenehan), a retiree taking full advantage of her newfound sexual freedom at a retirement community; Chelsea Healey (Tracee Chemo), a model housewife with a dark side; Yvonne Watson (Da'Vine Joy Randolph), a successful door-to-door cosmetics saleswoman; Don the White (Bjorn Gustafsson), a tall barista with a ponytail, alabaster skin and what some might call an otherworldly capacity for positive thinking; and Jeff the Grey (Ken Hall), an extremely pragmatic guy who's ready and willing to serve as logistics manager for any potential alien invaders.

Gina's support group meets in the community room of Our Lady of Sorrows in the small town of Beacon, renting the space through Father Doug (Oscar Nunez). Also playing a role in Ozzie's life is his gregarious boss, Jonathan Walsh (Michael Cassidy), who harbors an even greater secret of his own.