Partners is a comedy based on the lives of creators David Kohan and Max Mutchnick, about two life-long best friends and business partners whose "bromance" is tested when one of them is engaged to be married. Joe (David Krumholtz) is an accomplished architect who leads with his head and not his heart, especially in his love life. That's in stark contrast to his gay co-worker, Louis (Michael Urie), who is spontaneous, emotional and prone to exaggeration. Both have found joy in their love lives: Joe is newly engaged to Ali (Sophia Bush), a beautiful and sophisticated jewelry designer, while Louis is dating Wyatt (Brandon Routh), a vegan nurse who Louis insists is just a promotion away from becoming a doctor. As news of Joe's engagement settles, time will tell if their business and personal bond can adapt to the addition of two other important relationships.