"Blood & Treasure" is a globe-trotting action-adventure drama about a brilliant antiquities expert and a cunning art thief who team up to catch a ruthless terrorist who funds his attacks through stolen treasure. Danny McNamara (Matt Barr) is a former FBI agent specializing in stolen art and antiquities. Lexi Vaziri (Sofia Pernas) is a resourceful art thief who is haunted by the tragic loss of her father, which she blames on Danny. When terrorist Karim Farouk (Oded Fehr) absconds with a priceless artifact and kidnaps Danny's mentor Dr. Anna Castillo (Alicia Coppola), Danny recruits Lexi to help him bring Farouk to justice and rescue Anna.

As they chase down Farouk, they encounter unscrupulous individuals who may either be useful allies or dangerous enemies, including Aiden Shaw, an arms dealer who acts solely in his self-interest, and Simon Hardwick (James Callis), an expert at procuring pilfered artifacts. Danny and Lexi are assisted by Father Chuck (Mark Gagliardi), a childhood friend of Danny's who works at the Vatican Foreign Ministry in Rome. Their hunt draws the attention of Interpol agent Gwen Karlsson, who wants Farouk brought to justice, but won't allow Danny and Lexi to break international laws in the process. As they crisscross the world hunting their target, Danny and Lexi unexpectedly find themselves in the center of a 2,000-year-old battle for the cradle of civilization.