In a world where the balance between humans and wildlife is shattered, "Zoo" takes viewers on a thrilling adventure as animals across the globe begin to exhibit uncharacteristic behavior, leading to unprecedented attacks on humans. The story follows a diverse group of individuals, including the determined zoologist Jackson Oz, portrayed by James Wolk, who is driven by a deep love for animals and a desire to understand the chaos unfolding around them. Alongside him is the resourceful and intelligent Jamie, played by Kristen Connolly, whose scientific expertise proves invaluable as they confront the escalating crisis.

As they navigate treacherous environments, the team also includes the rugged former military man Abraham, portrayed by Billy Burke, and the fierce animal rights activist Chloe, played by Nora Arnezeder, each with their own motivations for joining the fight. Together, they must unravel the mystery behind this global phenomenon while battling not only the animals but also human antagonists seeking to exploit the situation.

The series blends drama, adventure, and thriller elements, creating a tense atmosphere as the characters face moral dilemmas and life-threatening challenges. With each episode, "Zoo" builds upon its central conflict, inviting viewers to ponder the consequences of humanity's actions on the natural world while keeping them on the edge of their seats.