The Spoils Before Dying is a debaucherous pulp-noir murder mystery set in the seedy underbelly of Los Angeles' jazz scene. It follows Rock Banyon (Michael Kenneth Williams) as he becomes the prime suspect in the double murder of his occasional lover Fresno Foxglove (Maya Rudolph) who is found dead with another man. Panicked, Rock splits for Mexico where he reunites with his one-time big band singer Delores DeWinter (Kristen Wiig).

With 72-hours to clear his name or fry in the electric chair, Rock and Delores embark on a dangerous quest for the truth that takes them into an abyss of sex, drugs, betrayal, and of course, jazz. While his world crumbles, Rock's hard-charging manager Alistair St. Barnaby (Haley Joel Osment) pressures him to record a mainstream jazz album.