In "Superman & Lois", after years of facing megalomaniacal supervillains, monsters wreaking havoc on Metropolis, and alien invaders intent on wiping out the human race, the world's most famous superhero, The Man of Steel aka Clark Kent (Tyler Hoechlin) and comic books' most famous journalist, Lois Lane (Elizabeth Tulloch), come face to face with one of their greatest challenges ever - dealing with all the stress, pressures and complexities that come with being working parents in today's society.

Complicating the already daunting job of raising two boys, Clark and Lois must also concern themselves with whether or not their sons Jonathan (Jordan Elsass) and Jordan (Alexander Garfin) could inherit their father's Kryptonian superpowers as they grow older. Returning to Smallville to handle some Kent family business, Clark and Lois are reacquainted with Lana Lang (Emmanuelle Chriqui), a local loan officer who also happens to be Clark's first love, and her Fire Chief husband Kyle Cushing (Erik Valdez).

The adults aren't the only ones rediscovering old friendships in Smallville as the Kent sons are reacquainted with Lana and Kyle's rebellious daughter, Sarah (Inde Navarrette). Of course, there's never a dull moment in the life of a superhero, especially with Lois' father, General Samuel Lane (Dylan Walsh) looking for Superman to vanquish a villain or save the day at a moment's notice. Meanwhile, Superman and Lois' return to idyllic Smallville is set to be upended when a mysterious stranger (Wole Parks) enters their lives.