In the chaotic household of the Oota family, middle schooler Eita Oota is desperate for a quiet, normal life, but his eccentric older sister, Makina, has other plans. Makina is a beautiful and brilliant inventor, but her obsessive passion for creating bizarre and often dangerous gadgets turns their home into a veritable laboratory of madness. From a machine that forcibly swaps personalities to a device that controls the weather indoors, her inventions consistently disrupt Eita's attempts at peace, much to his horror and embarrassment. The central conflict of this slapstick comedy revolves around Eita’s constant struggle to keep his sister’s outlandish creations a secret from their friends and neighbors, especially when they inevitably malfunction at the worst possible moments. Starring Yurie Kozakai as the voice of the hyperactive Makina and Kazuki Ura as the long-suffering Eita, Kakushite! Makina-san!! delivers a whirlwind of high-energy, gag-driven humor, blending familial affection with absolute absurdity as one brother tries to survive his sister's genius.