"Girlfriends' Guide to Divorce," follows the famous author of a best-selling self-help book series who is hiding the fact that she's separated from her husband as she starts to navigate her life as a single woman in her early 40s in Los Angeles. She finds herself seeking advice from her divorced friends, instead of her married ones which leads to some unexpected and life-changing experiences.

This season, the women deal with redefining themselves while experiencing significant changes in their personal and professional lives. Abby struggles to revamp her image and figure out what's next after her meeting with SheShe goes awry. With her ex Jake (Paul Adelstein) handling finances, Abby switches gears to try her hand at romance novels and finds inspiration from her son's enigmatic baseball coach, Mike (James Lesure).

After being left at the altar, Delia (Necar Zadegan) questions if she is marriage material and focuses her attention on getting her career back on track. Jo (Alanna Ubach) takes a risk mixing business and pleasure with her sex addict head baker Scott (Will Kemp) while also dealing with the repercussions of her alcoholic ex-husband Frumpkis (Maury Sterling). Barbara (Retta) gets a new role at SheShe and treats herself to a kitchen renovation, bringing a new man into her life, handsome contractor Darrell (Malcolm-Jamal Warner), who just may fix more than her stove.

Meanwhile, Phoebe (Beau Garett) deals with the consequences of rushing into her marriage with J.D (Aaron Staton) and finds escape in her friendship with a charismatic billionaire named Gemma (Daisy Betts).

This 4th season on "Girlfriends' Guide to Divorce" each of the women take their lives into their own hands and boss up. With dating on the back burner, Abby and Barbara decide to go into business together and create a website geared toward women their age called Lady Parts. Although both ladies have the company's best interest in mind, their leadership styles begin to clash.

With the site in need of an influencer, Abby and Barbara attempt to court starlet Temple Hampton (Denise Richards) who is dating Abby's ex, Will (Warren Christie). Jo continues to grow at Tao of Rex, her boxing and meditation group, and so does her relationship with the "Bald Eagle" aka Albert (Brian Markinson). When his true identity is revealed, Jo is forced to decide between love and friendship. Delia's new position at Legal Aid gives her a humanitarian high, only to be threatened by developing feelings for her new partner, Paul Cordero (Ignacio Serrichio).

Meanwhile, Phoebe continues her relationship with Gemma (Daisy Betts), but is left realizing she needs to reevaluate her priorities if she is going to salvage her marriage with JD (Aaron Stanton). After a family emergency rocks Abby's world, and elicits the return of her family George (Barry Bostwick), Dina (Lesley Ann Warren) and Max (Patrick Heusinger), she needs the help of all her girlfriends to keep from spiraling out of control.