Dominion is an epic supernatural drama set in the near future. Specifically, 25 years after "The Extinction War," when an army of lower angels, assembled by the archangel Gabriel, waged war against mankind. The archangel Michael, turning against his own kind, chose to side with humanity. Rising out of the ashes of this long battle are newly fortified cities which protect human survivors. At the center of the series is the city of Vega, a glistening empire that has formed from the ruins of what was once Las Vegas.

In Dominion's second season, humanity continues its struggle against the archangel Gabriel and his army of angels. Alex journeys from Vega to the legendary city of New Delphi, a human enclave with a dark secret, hoping to secure a military alliance with its charismatic leader. Back in Vega, Claire Riesen faces a civil war, pitting her against the disgraced David Whele and his newfound rebel allies. While war rages in the few cities left on earth, Michael stumbles upon a mystery in the form of Mallory, a perfect small town seemingly untouched by mankind's war with the angels.