Based on the acclaimed novel by Kem Nunn, "Chance" is described as a provocative psychological thriller that focuses on Eldon Chance (Laurie), a San Francisco-based forensic neuropsychiatrist who reluctantly gets sucked into a violent and dangerous world of mistaken identity, police corruption and mental illness. After an ill-advised decision regarding an alluring patient, Jaclyn Blackstone (Mol) who may or may not be struggling with a multiple personality disorder, Chance finds himself in the crosshairs of her abusive spouse, who also happens to be a ruthless police detective.

In over his head, Chance's decent into the city's shadowy underbelly, all while navigating the waters of a contentious divorce and the tribulations of his teenage daughter, soon spirals into an ever deepening exploration of one of mankind's final frontiers - the shadowy, undiscovered country of the human mind.

In season 2, the detective coerces Chance into helping him take down a serial killer. Chance finds himself 'laying in the nest' of the killer, in a dangerous game to prove the man guilty. His reckless behavior also puts him at odds with D [Ethan Suplee], who has begun to question the black and white nature of his own vigilantism. When the walls of the system collapse in on him, Chance is forced to reassess his life's work and questions if violence is really the answer.