Are We There Yet? opens where the popular film left off, with Nick (Crews) and Suzanne (Atkins) newly married. After six months, their family is beginning to show growing pains, from the complexities of life as newlyweds to weathering the storm of teenage children. Work makes life all the more complicated. Former athlete Nick has sold his sports paraphernalia store and now works in information technology. Party planner Suzanne also has a hectic professional schedule.

Teala Dunn and Coy Stewart co-star as Lindsey and Kevin, Nick and Suzanne's 14 and 10-year-old children. They spend their time texting friends and playing on the computer instead of connecting with family. Telma Hopkins (Family Matters) plays Nick's mother, who isn't happy about his marriage or her new role as a grandmother. Keesha Sharp (Girlfriends, Why Did I Get Married) is Suzanne's best friend; she has a taste for men and the finer things in life. Comedian Christian Finnegan plays Nick's best friend and owner of a sports memorabilia store. Ice Cube plays a recurring role as Suzanne's SWAT officer brother.