The rapper, who founded the festival in his home town in 2018, shared his condolences to the families of those who died at the event held outside NRG Park.
"I'm absolutely devastated by what took place last night," Scott shared to Twitter on Saturday morning.
"My prayers go out to the families and all those impacted by what happened at Astroworld Festival."
"Houston PD (police department) has my total support as they continue to look into the tragic loss of life."
"I am committed to working together with the Houston community to heal and support the families in need. Thank you to Houston PD, Fire Department and NRG Park for their immediate response and support."
"Love You All."
The crowd was estimated at 50,000, the Houston Chronicle reports.
At a press conference following the concert, Houston Fire Chief Samuel Pena stated the crowd began "surging" towards the stage.
"We had at least eight confirmed fatalities tonight and scores of individuals that were injured," he said.
"The crowd began to compress towards the front of the stage, and that caused some panic, and it started causing some injuries. People began to fall out, become unconscious, and it created additional panic."
According to reports, Scott paused the show several times to ask security to help out fans.