The "Hidden Figures" star will team up with Cynthia Erivo, who will play the revered abolitionist in Harriet, which follows the African-American icon's escape from slavery in 1849 and her subsequent missions to rescue dozens of slaves.
Kasi Lemmons of "Eve's Bayou" fame will direct from a screenplay she co-wrote with Gregory Allen Howard, alongside Oscar-winning cinematographer John Toll, who has worked on movie epics Legends of the "Fall" and "Braveheart".
Leslie Odom Jr., Taylor Swift's actor boyfriend Joe Alwyn, Jennifer Nettles, Clarke Peters, and Vanessa Bell Calloway will also appear in the movie, which will begin filming in Virginia later this month.
A release date has yet to be confirmed.
Meanwhile, Monae will also be seen and heard in "UglyDolls", which is based on the popular plush toys created by David Horvath and Sun-Min Kim.
The movie will centre on the residents of Uglyville, who have to confront body image issues as they learn to love themselves.
Monae, Clarkson, Jonas, and Pitbull will also contribute new music for the movie's soundtrack.
The children's project, designed to launch a new film franchise, is set to hit theatres in May, 2019.