Animated comedy "Housebroken" follows a group of neighborhood pets and stray animals as they work through their issues inside and outside their therapy group. Honey (Lisa Kudrow), a standard poodle, opens her living room for the group to come and support each other through the misery, mayhem and majesty that is being a pet. Honey also struggles with her own problems, such as her arranged (by her human) marriage with Chief (Nat Faxon), a sloppy St. Bernard who enjoys eating socks and licking himself.

The group includes Shel (Will Forte), a sex-positive tortoise with intimacy issues and a knack for choosing unconventional partners; Tabitha (Sharon Horgan), an aging Persian cat beauty queen, trying to adjust to life off the cat show circuit; The Gray One (Jason Mantzoukas), a street smart cat who lives with about thirty other cats and has his one eye on Tabitha; Chico (Sam Richardson), a chonky, co-dependent and very naive cat; and the group's newest member, Diablo (Tony Hale), an anxious, sweater-wearing terrier whose OCD causes him to hump everything twice.

Among the group's other members are Elsa (Clea DuVall), a power hungry, know-it-all Corgi, and fake service dog, who drives Honey crazy; Nibbles (guest voice Bresha Webb), a psychopathic hamster who is mourning the loss of her mate (whose face she ate...and everyone knows it); Max (Hale), George Clooney's pig, a former actor and current status obsessed a-hole; Bubbles (guest voice Greta Lee), a horny, teenage goldfish who lives with Honey and Chief, and heckles the animals any chance she gets; Tchotchke, a silent, and possibly magical, slow loris with a mysterious past, who uses a tiny cocktail umbrella to express his emotions; and Jill (guest voice Maria Bamford), Honey and Chief's human owner.

"Housebroken" is an irreverent look at human behavior, but told through the filter of an offbeat group of neighborhood pets. Throughout the series, the show centers on the pets' dysfunctional relationships and their skewed world view, while exploring relevant societal issues in fun and unique ways.