The investigations that Mulder and Scully previously began with conspiracy theorist and web-TV show host Tad O'Malley (guest star Joel McHale) seem to have awakened powerful enemies. A widespread panic begins as people all over the country suddenly start falling gravely ill, and Scully must look within to try and find a cure. Meanwhile, Mulder confronts the man whom he believes to be behind it all, but another figure from Mulder and Scully's past may prove to be the key to their salvation.
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