As Audrey Bayer (Holly Hunter) puts the finishing touches on her husband Greg's 60th birthday party - a milestone Greg (Tim Robbins) is loath to celebrate - cracks begin to emerge in their progressive, multiracial family. Ramon (Daniel Zovatto), the couple's Colombian-born son, who's just starting a relationship with Henry (Andy Bean), a barista, is having unexplained, recurring encounters with the numbers "11:11". Duc (Raymond Lee), adopted from Vietnam, enjoys the fruits of a lucrative career as a "motivational architect," but his celibacy troubles Audrey.
Liberian-born Ashley (Jerrika Hinton), a successful fashion-industry exec, is finding more and more reason to shake up her marriage with her husband, Malcolm (Joe Williamson). And 17-year-old Kristen (Sosie Bacon), the couple's youngest child, chafes at her banal life, especially compared to her more exotic siblings.
After a troubling incident at the birthday party, Audrey and Greg take Ramon to a therapist, Dr. Farid Shokrani (Peter Macdissi), who has an unlikely and unexplainable connection to the young man.