| Episode | Title | Premiere |
|---|---|---|
| 10 | The Pornscape | September 29, 2017 |
| 09 | I Survived Jessi's Bat Mitzvah | September 29, 2017 |
| 08 | The Head Push | September 29, 2017 |
| 07 | Requiem for a Wet Dream | September 29, 2017 |
| 06 | Pillow Talk | September 29, 2017 |
| 05 | Girls Are Horny Too | September 29, 2017 |
| 04 | Sleepover: A Harrowing Ordeal of Emotional Brutality | September 29, 2017 |
| 03 | Am I Gay? | September 29, 2017 |
| 02 | Everybody Bleeds | September 29, 2017 |
| 01 | Ejaculation | September 29, 2017 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | The Department of Puberty | October 5, 2018 |
| 09 | Smooch or Share | October 5, 2018 |
| 08 | Dark Side of the Boob | October 5, 2018 |
| 07 | Guy Town | October 5, 2018 |
| 06 | Drug Buddies | October 5, 2018 |
| 05 | The Planned Parenthood Show | October 5, 2018 |
| 04 | Steve the Virgin | October 5, 2018 |
| 03 | The Shame Wizard | October 5, 2018 |
| 02 | What Is It About Boobs? | October 5, 2018 |
| 01 | Am I Normal? | October 5, 2018 |
| Episode | Title | Premiere |
|---|---|---|
| 11 | Super Mouth | October 4, 2019 |
| 10 | Disclosure the Movie: The Musical! | October 4, 2019 |
| 09 | The ASSes | October 4, 2019 |
| 08 | Rankings | October 4, 2019 |
| 07 | Duke | October 4, 2019 |
| 06 | How To Have An Orgasm | October 4, 2019 |
| 05 | Florida | October 4, 2019 |
| 04 | Obsessed | October 4, 2019 |
| 03 | Cellsea | October 4, 2019 |
| 02 | Girls Are Angry Too | October 4, 2019 |
| 01 | My Furry Valentine | February 8, 2019 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | What Are You Gonna Do? | December 4, 2020 |
| 09 | Horrority House | December 4, 2020 |
| 08 | The Funeral | December 4, 2020 |
| 07 | Four Stories About Hand Stuff | December 4, 2020 |
| 06 | Nick Starr | December 4, 2020 |
| 05 | A Very Special 9/11 Episode | December 4, 2020 |
| 04 | Cafeteria Girls | December 4, 2020 |
| 03 | Poop Madness | December 4, 2020 |
| 02 | The Hugest Period Ever | December 4, 2020 |
| 01 | The New Me | December 4, 2020 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | Re-New Year's Eve | November 5, 2021 |
| 09 | Sugarbush | November 5, 2021 |
| 08 | A Very Big Mouth Christmas | November 5, 2021 |
| 07 | I F**king Hate You | November 5, 2021 |
| 06 | Best Friends Make the Best Lovers | November 5, 2021 |
| 05 | Thanksgiving | November 5, 2021 |
| 04 | The Green-Eyed Monster | November 5, 2021 |
| 03 | Lovebugs | November 5, 2021 |
| 02 | The Shane Lizard Rises | November 5, 2021 |
| 01 | No Nut November | November 5, 2021 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | F**ked Up Friday | October 28, 2022 |
| 09 | The Parents Aren't Alright | October 28, 2022 |
| 08 | Asexual Healing | October 28, 2022 |
| 07 | Dadda Dia! | October 28, 2022 |
| 06 | The Apple Brooch | October 28, 2022 |
| 05 | Andrew's Gonna Touch A Boob Tonight | October 28, 2022 |
| 04 | Rice Purity Test | October 28, 2022 |
| 03 | Vagina Shame | October 28, 2022 |
| 02 | Twenty Two and You | October 28, 2022 |
| 01 | The Hookup House | October 28, 2022 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | A Finger in Time | October 20, 2023 |
| 09 | Panic! At the Mall | October 20, 2023 |
| 08 | The Bad Hookup | October 20, 2023 |
| 07 | Get the F**k Outta My House | October 20, 2023 |
| 06 | The International Show | October 20, 2023 |
| 05 | Graduation | October 20, 2023 |
| 04 | Day Tripping | October 20, 2023 |
| 03 | The Ambition Gremlin | October 20, 2023 |
| 02 | Epididymitis | October 20, 2023 |
| 01 | Big Mouth's Going to High School (But Not for Nine More Episodes) | October 20, 2023 |
| Episode | Title | Premiere |
|---|---|---|
| 10 | The Great Unknown | May 23, 2025 |
| 09 | Everything We Forgot to Tell You About Sex | May 23, 2025 |
| 08 | Horny Talky Yes Please | May 23, 2025 |
| 07 | Have Some Goddamn Compassion | May 23, 2025 |
| 06 | Everyone Watches Porn | May 23, 2025 |
| 05 | Am I Smoking Too Much Weed? | May 23, 2025 |
| 04 | Lola Skumpy: License to Drive | May 23, 2025 |
| 03 | Why Do We Go Through Puberty? | May 23, 2025 |
| 02 | Cliques, Pricks, and Sonic's Dick | May 23, 2025 |
| 01 | Homecumming | May 23, 2025 |
