The actress - who played Mary-Jane Watson opposite Tobey Maguire as Peter Parker in three movies - would jump at the opportunity to reprise the role for a fourth time, after playing her in Sam Raimi's "Spider-Man", "Spider-Man 2" and "Spider-Man 3", and thinks it would be "fun" to return to the character.
She told Variety, "I would do it. Why not? That would be fun. I would never say no to something like that."
But Kirsten joked things would be different for her character now as so much time has passed since 2007's "Spider-Man 3". She quipped, "I'd be an old MJ at this point with little Spidey babies."
Rumors have circulated about previous stars from the "Spider-Man" franchise making cameos in "Spider-Man: No Way Home" - which is touted for a December 17 release date. However, Kirsten has denied that she'll be making an appearance in the movie.
In an interview with Total Film, the 39-year-old actress set the record straight. "I'm not in that movie, no," she insisted. "I know there's rumors, right?"
Kirsten went on to note that she had not watch the newer version of "Spider-Man" movies. "I haven't seen any of them. I don't watch superhero movies, though. I don't watch anything like that. It's just not my kind of movie," she stated.
"I can't tell you the last time I saw one. I think I saw maybe 'Captain America' with my friend in a theater, which was - what? - a long time ago when that first came out," the mother of two continued. "I just don't watch them."