The actress hasn't ruled out a return to the teen drama - in which she played Brooke Davis - and teased the cast have been in talks about a possible reboot.
Asked about the possibility, she told Entertainment Tonight, "I mean, I can't spill all of our secrets, but I'd say never say never."
The "Chalet Girl" star recently reunited with Hilarie and Bethany - who played Peyton Sawyer and Haley James, respectively - for their new podcast "Drama Queens".
They decided to launch their own series after Sophia noticed fans were rewatching "One Tree Hill" during the coronavirus lockdown.
"I noticed that on social media, all these people were saying they were (rewatching) One Tree Hill ... And I was like, 'Is this our moment? ... Should we do this now?' " she explained.
"So I called Hilarie and I said, 'You tell me if this is crazy, but you left first, so I'm asking you first. What do you think?' She was like, 'Yeah, I'm in. Call Joy.' I was like, 'All right, I'm adding her in.' I called Joy and we were just like, 'Yeah, let's do this.' "