Murray Fraser and Parisa Fitz-Henley portrayed the royals in the 2018 TV movie, which chronicled the now-married couple's relationship up until their engagement, and the new film, "Harry & Meghan: Becoming Royal", will "pull back the curtain to reveal the untold joys and challenges of life inside the royal family during their pivotal first years of marriage".
Production will begin later this month in Vancouver, but Fraser and Fitz-Henley will not be reprising their roles in the new movie.
"Unfortunately our original royal couple, Murray and Parisa, are not available, so more news to come on who will take their crowns," A+E president of programming Rob Sharenow said at the Television Critics Association's winter press tour on Sunday, February 10.
It is also unclear if the movie will feature Prince Harry and Meghan, Duchess of Sussex's unborn baby, who is due in April.
A premiere date has yet to be announced, but the film will be released later this year.