"One Mississippi" is a dark comedy inspired by comedian Tig Notaro's life. Tig returns to her hometown in Mississippi, where she contends with the death of her mother and her own mortality as she embarks on a painful yet hilarious journey that unearths uncomfortable truths about her family and her self.

Love is in the air in when we pick back up with Tig (Tig Notaro), her stepfather Bill (John Rothman) and her brother Remy (Noah Harpster), living together again in the family's home in Mississippi. It's a season of new beginnings and new relationships for each of them, all of which test their personal status quo... as well as family boundaries. Tig resumes her radio career in Biloxi with producer Kate (Stephanie Allynne) by her side, though her outspoken point of view proves controversial for the local market. An opportunity to take a bigger stage in New Orleans comes with more reach, and also more responsibility.