'Life in Pieces' is a single-camera comedy about one big happy family and their sometimes awkward, often hilarious and ultimately beautiful milestone moments as told by its various members. Of the three siblings, middle child Matt may have just found his true love, his co-worker, Colleen; his coddled youngest brother, Greg, and his wife, Jen, are overwhelmed by the birth of their first child; and the eldest, Heather, and her husband, Tim, are dreading their impending empty nest so much, they're considering having another baby. Their parents are Joan, the family's adoring matriarch who would do anything for her kids - as long as she agrees with it - and John, the gregarious patriarch who's searching for ways to soften the blow of turning 70. As the family's lives unfold in four short stories each week, they try to savor these little pieces of time that flash by but stay with you forever, because these moments add up to what life's all about.

In the second season premiere, Matt moves into Colleen's apartment but faces some serious resistance from Colleen's roommate; Heather and Tim reach out to Clementine's parents (guest stars Megan Mullally and Nick Offerman) to get Tyler and Clementine's (new series regular Hunter King) marriage annulled; John lands in the hospital after some medication results in an embarrassing side effect; and Jen and Greg are forced to reveal a secret when they walk into a surprise baby shower.