In Grace and Frankie, Jane Fonda ("Grace") and Lily Tomlin ("Frankie") star as two women whose lives are suddenly turned upside down when their husbands reveal they are gay and leave them for each other. Both sparring partners and partners-in-crime, they form an unlikely bond to face an uncertain future together and discover a new definition of "family," with laughter, tears and plenty of mood enhancers along the way.

With their ex-hubbies now married to each other and their clans more integrated than ever, Grace and Frankie continue to struggle to make sense of the brave new world that is their lives. Frankie copes by getting more involved in Brianna's business.