Based on Taffy Brodesser-Akner's best-selling novel, "Fleishman Is In Trouble" centers on recently separated fortysomething Toby Fleishman (Jesse Eisenberg), who dives into the brave new world of app-based dating with the kind of success he never had dating in his youth, before he got married at the tail end of medical school. But just at the start of his first summer of sexual freedom, his ex-wife, Rachel (Claire Danes), disappears, leaving him with the kids and no hint of where she is or whether she plans to return.