In Falling Skies, Noah Wyle stars as Tom Mason, a college professor who became an unlikely resistance leader following a massive invasion by an alien race known as the Espheni. Bloodgood is Dr. Anne Glass, a pediatrician who became the survivors' primary physician and newly battle-hardened losing her daughter in a battle to destroy the alien power core. Patton is Colonel Weaver, the gruff and emotionally scarred commander of the 2nd Mass who has been leading the battle against the invaders.

Last season on Falling Skies, the Mason family and the remaining 2nd Mass found themselves under brutal attack by a new Espheni war machine - and a new, deadly creation unlike anything previously encountered. Divided like chattel and spread to the winds, they forged new relationships and fought harder than ever in order to survive.

As season five opens, all breed of beast and mutant are running rampant on earth. The Espheni's power core has been destroyed, and humans are now ready to fight on their terms, even if it means resorting to hand-to-hand combat against the enemy. After four years of being tortured, imprisoned and mutated and having their loved ones stolen from them, Tom and the 2nd Mass are filled with rage, ready to destroy the enemy in an all-out battle to determine the fate of Earth.