A successful and dedicated neurosurgeon goes missing after an evening run with her ex-husband. Jack is instantly suspicious of the friendly nature of her relationship with her ex, but soon other suspects emerge, including a patient's grieving family, another doctor at the hospital, and a patient with a junkie boyfriend, known to have been personally involved with the missing doctor. However, when the team discover that the doctor gave up a baby for adoption over 20 years ago, and that she recently tried to make contact with her daughter, they begin to think that the missing woman may have been struggling emotionally recently and that she may have been manipulated by someone with information about her daughter.
