A vast international plot explodes when a beautiful Jane Doe is discovered naked in Times Square, completely covered in mysterious, intricate tattoos with no memory of who she is or how she got there. There's one that's very clear, however: the name of FBI agent Kurt Weller, emblazoned across her back. "Jane," Agent Weller and rest of the FBI quickly realize that each mark on her body is a crime to solve, leading them closer to the truth about her identity and the mysteries to be revealed.

At the center of this mystery is the relationship between Weller and Jane Doe. With every passing day, Jane unveils a new skill or a hidden talent without understanding its origin, while Weller is drawn deeper into his troubled, complicated relationship with this enigmatic woman. They both strive to make a connection, unaware of the dangerous blindspot that threatens them.