DJ Khaled joins Kenan Thompson and John C. Reilly in a humorous Super Bowl ad for Wegovy, promoting its transformative weight loss benefits.
- February 7, 2026
AceShowbiz - DJ Khaled is making headlines with his appearance in Novo Nordisk's Super Bowl LX advertisement featuring the Wegovy pill. The renowned rapper and producer is part of an ensemble cast that includes comedic talents like Kenan Thompson, John C. Reilly, and Ana Gasteyer, all promoting the innovative GLP-1 weight loss medication.
Set to air during the big game on Sunday, February 8, the 90-second commercial highlights the transformative benefits of Wegovy, now available in pill form. In this lively spot, Kenan Thompson delivers the exciting news from atop a water tower, announcing, “Wegovy now comes in a pill.” Below, a spirited DJ Khaled enthusiastically responds, emphasizing that adults dealing with obesity can effectively manage their weight alongside a balanced diet and exercise.
The humorous ad, accompanied by the nostalgic beats of Skee-Lo's 1995 hit “I Wish,” showcases various celebrities humorously expressing their desires for other fantastical pills. For instance, John C. Reilly whimsically wishes for a pill to master parallel parking, while DJ Khaled dreams of a pill that could turn him into a professional wrestler. Additionally, actress Danielle Brooks longs for a pill to assist her in rescuing more kittens, showcasing her playful side as she hands a cat to tough-guy Danny Trejo. Meanwhile, Ana Gasteyer humorously ponders a pill to make people “less judgy about how to lose weight.”
This advertisement marks the debut of Novo Nordisk's once-daily Wegovy 25mg tablets, aiming to reshape public perceptions surrounding weight loss medications. Rather than being seen as an easy solution, the ad stresses that Wegovy can be an effective part of a broader lifestyle change, combined with healthy eating and physical activity.
In a recent statement, DJ Khaled expressed his motivation for collaborating with Novo Nordisk, reflecting on his personal experiences: “I know what it’s like to go hard in the gym, eat clean, stay disciplined – put in that work every single day, but still not see the results you want. I knew I wanted to work with Novo Nordisk because I’m a father, I’m a husband, and I want to be the best for my family.”
This engaging ad not only highlights the Wegovy pill but also showcases the importance of a comprehensive approach to weight management, encouraging a dialogue about health and wellness. Fans of DJ Khaled and the other stars featured in the commercial can look forward to a memorable Super Bowl moment that combines entertainment with a meaningful message.