AceShowbiz - Martin Short brought his signature humor to his first night as guest host on the late-night show, taking aim at Donald Trump and Joe Biden with a series of political jabs.

Martin kicked off his monologue by asking sidekick Guillermo Rodriguez, "What would Jimmy usually do right now?" Rodriguez replied, "He would be talking about Donald Trump."

Undeterred, Martin quipped, "Well, I guess you can't go to Outback Steakhouse without ordering the Bloomin' Onion," before launching into his political commentary.

"Donald Trump says he's close to announcing his running mate, and has reportedly narrowed it down to three people. It was four, but O.J. died."

Martin also mocked Trump's suggestions that Biden would be using stimulants before the debates. "He says he wants them both to submit to a drug test before the debate," said Martin. "Do you have any idea how long it takes to get a urine sample from men who are close to 80? I'm 74, and the only time I don't have to pee is when I'm peeing."

After delivering his opening night monologue, Martin welcomed his friend and "Only Murders in the Building" co-star, Steve Martin, to the stage. The duo traded some passive-aggressive barbs, with Steve playfully insulting Martin's appearance and work ethic.

Martin said he declined the offer to guest host because he knew they could find someone else "who'll do it for scale." Martin added, "There are very few people in this world that I truly admire, and Steve Martin is very close to being one of them."