Madison Walker (Sarah Roemer, "Disturbia", "Grudge 2") a young woman living in New Orleans, struggles to lead a normal life after suffering a series of personal tragedies. Unsuccessful, she finally succumbs to a failed suicide attempt which lands her in a mental institution. Once there, Madison must begin navigating the dreaming and waking worlds of the real and unreal. As she pierces the veil of these two worlds, psychiatrist Dr. Elisabeth Barnes (Academy Award nominee Elisabeth Shue) assists Madison in revealing the truth of her reality. In her attempt to prevent Madison from self-destruction, Dr. Barnes unleashes a dark past that leads to a shocking conclusion that neither expect. Waking Madison takes us on a spiraling journey of the mind where things are rarely what they seem.