Don Tillman, a professor of genetics may suffer from Aspergers and has never been on a second date until he embarks upon The Wife Project, designing a questionnaire to help him find the perfect partner: a punctual, non-drinking, non-smoking female who will fit in with his regimented lifestyle. When the unorthodox and free-spirited Rosie appears on the scene, it is clear that she fits none of his selection criteria, but she still may just be the perfect match to help turn his life around.