"Night Owls" follows workaholic Kevin (Pally), who goes home with beautiful train-wreck Madeline (Salazar) for a drunken one-night-stand, and is then horrified to discover she's actually his boss' jilted ex-mistress.

After Madeline takes a bottle of sleeping pills, Kevin is forced to keep her awake all night. As Madeline and Kevin banter through the night, they begin to fall for each other.