After the death of his wife, Carson Drew (Sam Trammell) decides to leave Chicago behind and make a fresh start with his daughter 16-year-old daughter Nancy (Sophia Lillis) in River Heights. Nancy is asked by Flora (Linda Lavin) to help solve the ghostly activity at her home, the Twin Elms mansion. Can she help explain the creaking footsteps, exploding lightbulbs and the ominous creature? Is it the handiwork of high-school bully Derek Barnes (Evan Castelloe)? Or is it possible that the ghost of original owner Malcolm Colfax is back for revenge? Recruiting her best friends George (Zoe Renee) and Bess (Mackenzie Graham), along with local "mean girl" Helen (Laura Wiggins), Nancy Drew is on the case!