"Isolation" is a thriller inspired by the true events of a couple (Tricia Helfer/Luke Mably) who are vacationing on a remote island in the Bahamas. Upon arriving they explore their new surroundings and ultimately run into two other couples (Dominic Purcell/Marie Avgeropoulos & Stephen Lang/Claudia Church) who invite them in for food and drink.

While out, their house is robbed and soon enough things start spiraling out of control. Unsure of who to trust, it soon becomes a game of cat and mouse as they fight for their lives.