"Hooking Up" follows Darla (Brittany Snow), a cynical reporter whose sex addiction is getting in the way of her sex column, and her evolving relationship with Bailey, a well-meaning sweetheart who's been dumped by his fiance and learns he has testicular cancer (again). Together they embark on an impromptu cross country road trip, recreating Darla's myriad trysts from state to state. She's looking for a story and he's looking for a last hurrah; what they find is something neither expected.