Based on Carrie Ryan's New York Times best-seller, the story is set "sometime in the future," in a world where most of the human race has been taken by a bloodthirsty virus that leaves them roaming the planet as cannibals. Mary (Williams) seeks a world beyond the fenced-off village of survivors.

The survival of the human race soon becomes dependent upon her success in leading a ragtag group through the dark depths of the Forest of Hands and Teeth.