A broken, aging comedian tours the California desert, lost in a cycle of third-rate venues, novelty tourist attractions, and vain attempts to reach his estranged daughter. By day, he slogs through the barren landscape, inadvertently alienating every acquaintance. At night, he seeks solace in the animation of his onstage persona.

Fueled by the promise of a lucrative Hollywood engagement, he trudges through a series of increasingly surreal and volatile encounters. In Alverson's hallucinatory fugue, Gregg Turkington stars as The Comedian, caught in a struggle between being the center of attention and the object of alienation, occasionally challenged by an unexpected cast of characters played by Tye Sheridan, John C. Reilly, Michael Cera, and Amy Seimetz.