After a disease kills 98% of America's children, the surviving 2% develop superpowers and are placed in internment camps. A 16-year-old girl escapes her camp and joins a group of other teens on the run from the government.

When teens mysteriously develop powerful new abilities, they are declared a threat by the government and detained. Sixteen-year-old Ruby (Amandla Stenberg), one of the most powerful young people anyone has encountered, escapes her camp and joins a group of runaway teens seeking safe haven. Soon this newfound family realizes that, in a world in which the adults in power have betrayed them, running is not enough and they must wage a resistance, using their collective power to take back control of their future.