Duke White (Harvey Keitel) hasn't been an ideal father to his five boys. An inveterate gambler who never experienced a windfall he couldn't blow within twenty-four hours, he has come to the end of his rope, literally. Years ago, he signed up his three eldest sons for unsafe drug tests that turned out to have dire consequences: the boys' life expectancy have been substantially reduced. Upon receiving the news after their father's funeral, the sons return to their family home in Niagara Falls, where they respond to their eminent demises in different yet equally hilarious ways.

Womanizing Cal (Scott Caan) is determined to hook up with Miranda (Tricia Helfer), the one girl who got away. Cautious Jacob (Paulo Costanzo), the only son with a real job, is determined to take every risk he didn't take earlier, usually accompanied by Duke's youngest son, Todd (Siam Yu). And finally there's his eldest, Nuts (Jason Jones), a boxer turned promoter who seems to have inherited his father's love of the calamitous long shot.