Traumatized ex-soldier Reeve (Clarke) wakes up in the back of a moving van alongside a young boy (Parkinson) held prisoner. But after helping the boy escape, he comes to the terrifying conclusion that he's the kidnapper. Even more startling, five years have passed since he was last awake. Ryan soon learns that he's caught up in a futuristic conspiracy known as "Anomaly," Ryan's only connection with reality is the dogged pursuit of Ryan by the elegant but sinister Harkin Langham (Somerhalder), who - when he's not trying to kill Ryan - explains how to survive his blackouts, lasting exactly 9 minutes and 47 seconds.

As he negotiates switching between parallel universes, Ryan teams up with the mysterious "Dana" (Knapp) to start unraveling the life-threatening mystery in which he's the explosive center. With Harkin dogging and thwarting his every turn, Ryan must summon all his will to challenge his programmed destiny and regain his humanity.