(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Outstanding Guest Actor in a Drama Series (For playing "Aaron Brooks", episode "Stranger's And Brother's") | Once and Again (1999) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Best Performance by an Actor in a Television Series - Drama | Grey's Anatomy (2005) (TV) | - |
| 2006 | N | Best Performance by an Actor in a Television Series - Drama | Grey's Anatomy (2005) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Best Kiss | Enchanted (2007) | Amy Adams |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | W | Favorite Dramatic TV Actor | - | - |
| 2014 | N | Favorite Dramatic TV Actor | - | - |
| 2012 | N | Favorite TV Drama Actor | - | - |
| 2011 | N | Favorite TV Drama Actor | - | - |
| 2011 | N | Favorite TV Doctor | As Derek Shepherd in Grey's Anatomy (2005) (TV) | - |
| 2010 | N | Favorite TV Drama Actor | - | - |
| 2009 | N | Favorite Male TV Star | - | - |
| 2008 | W | Favorite Male TV Star | - | - |
| 2007 | W | Favorite Male Television Star | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Outstanding Performance by an Ensemble in a Drama Series | Grey's Anatomy (2005) (TV) | Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, Isaiah Washington |
| 2007 | W | Outstanding Performance by an Ensemble in a Drama Series | Grey's Anatomy (2005) (TV) | Katherine Heigl, Sandra Oh, Ellen Pompeo |
| 2006 | N | Outstanding Performance by a Male Actor in a Drama Series | Grey's Anatomy (2005) (TV) | - |
| 2006 | N | Outstanding Performance by an Ensemble in a Drama Series | Grey's Anatomy (2005) (TV) | Katherine Heigl, Sandra Oh, Isaiah Washington |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Choice TV Actor: Drama | Grey's Anatomy (2005) (TV) | - |
| 2006 | N | TV - Choice Actor: Drama/Action Adventure | Grey's Anatomy (2005) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1988 | W | Best Young Actor in a Motion Picture - Comedy | Can't Buy Me Love (1987) | - |
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