(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Favorite TV Reality, Variety, or Comedy Personality or Act | - | - |
| 2011 | W | Favorite TV Reality, Variety, or Comedy Personality or Act | Lopez Tonight (2009) (TV) | - |
| 2009 | N | Best Actor in Comedy (Year in Television) | Mr. Troop Mom (2009) (TV Movie) | - |
| 2007 | W | - | - | - |
| 2007 | N | Outstanding Actor in a Television Series, Mini-Series, or TV Movie | George Lopez (2002) (TV) | - |
| 2006 | N | Outstanding Actor in a Television Series | George Lopez (2002) (TV) | - |
| 2002 | N | Outstanding Supporting Actor in a Motion Picture | Bread and Roses (2000) | - |
| 1999 | N | Outstanding Performance by an Individual or Act in a Variety or Comedy Special | 2nd Annual Latino Laugh Festival (1998) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Outstanding Lead Actor in a Comedy Series | George Lopez (2002) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2010 | N | Best Comedy Album | "Tall, Dark & Chicano" | - |
| 2008 | N | Best Comedy Album | "America's Mexican" | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | W | Best Actor - Feature Film | Spare Parts (2015) | - |
| 2009 | N | Best Actor - Feature Film | Beverly Hills Chihuahua (2008) | - |
| 2007 | N | Best Actor - Television | George Lopez (2002) (TV) | - |
| 2007 | N | Best Actor - Television | George Lopez (2002) (TV) | - |
| 2005 | N | Best Actor - Television | George Lopez (2002) (TV) | - |
| 2004 | W | Best Actor in a Television Comedy | George Lopez (2002) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Outstanding Actor in a Comedy Series | George Lopez (2002) (TV) | - |
| 2006 | N | Outstanding Actor in a Comedy Series | George Lopez (2002) (TV) | - |
| 2005 | N | Outstanding Actor in a Comedy Series | George Lopez (2002) (TV) | - |
| 2004 | N | Outstanding Actor in a Comedy Series | George Lopez (2002) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | N | Favorite Movie Actor | Beverly Hills Chihuahua (2008) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2011 | N | Favorite Talk Show Host | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2011 | N | Worst Supporting Actor | The Spy Next Door (2010), Marmaduke (2010), Valentine's Day (2010) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | N | Choice Comedian | - | - |
| 2011 | N | Choice Comedian | - | - |
| 2010 | N | Choice Comedian | - | - |
| 2009 | W | Choice Comedian | - | - |
| 2003 | N | Choice TV Breakout Star - Male | George Lopez (2002) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | W | Television (On 10 October 2006; At 6901 Hollywood Blvd.) | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Most Popular Mom & Pop in a Television Series | George Lopez (2002) (TV) | Constance Marie |
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