(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | Best Supporting Actress | Vanilla Sky (2001) | - |
| 2001 | N | Best Supporting Actress | Charlie's Angels (2000) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | AFI Featured Actor of the Year - Female - Movies | Vanilla Sky (2001) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2014 | W | Actress Most in Need of a New Agent | Sex Tape (2014) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Favorite Movie Actress Comedy/Musical | - | - |
| 2011 | N | Favorite Movie Actress - Comedy/Musical | Bad Teacher (2011) | - |
| 2009 | N | Best of the Year in Film - Actress | My Sister's Keeper (2009) | - |
| 2007 | N | Outstanding Actress in a Motion Picture | The Holiday (2006) | - |
| 2002 | N | Outstanding Supporting Actress in a Motion Picture | Vanilla Sky (2001) | - |
| 2000 | W | Outstanding Actress in a Feature Film | Any Given Sunday (1999) | - |
| 1999 | N | Outstanding Actress in a Feature Film in a Crossover Role | There's Something About Mary (1998) | - |
| 1998 | W | Outstanding Individual Performance in a Crossover Role in a Feature Film | My Best Friend's Wedding (1997) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Performance by an Actress | Bad Teacher (2011) | - |
| 2000 | N | Funniest Supporting Actress in a Motion Picture | Being John Malkovich (1999) | - |
| 1999 | W | Funniest Actress in a Motion Picture (Leading Role) | There's Something About Mary (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2011 | N | Voice Acting in a Feature Production | Shrek Forever After (2010) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Performance by an Actress in a Supporting Role | Being John Malkovich (1999) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Favorite Action Team (Internet Only) | Charlie's Angels (2000) | Drew Barrymore, Lucy Liu |
| 2000 | W | Favorite Actress - Drama | Any Given Sunday (1999) | - |
| 1999 | W | Favorite Actress - Comedy | There's Something About Mary (1998) | - |
| 1998 | W | Favorite Supporting Actress - Comedy | My Best Friend's Wedding (1997) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Best Supporting Actress | Vanilla Sky (2001) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | Best Supporting Actress | Vanilla Sky (2001) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Best Supporting Actress | Vanilla Sky (2001) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Supporting Actress | Being John Malkovich (1999) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2011 | W | - | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2003 | N | Best Performance by an Actress in a Supporting Role in a Motion Picture | Gangs of New York (2002) | - |
| 2002 | N | Best Performance by an Actress in a Supporting Role in a Motion Picture | Vanilla Sky (2001) | - |
| 2000 | N | Best Performance by an Actress in a Supporting Role in a Motion Picture | Being John Malkovich (1999) | - |
| 1999 | N | Best Performance by an Actress in a Motion Picture - Comedy/Musical | There's Something About Mary (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Best International Actress | Shrek 2 (2004) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | N | Best Actress | In Her Shoes (2005) | - |
| 2004 | W | Best Actress in a Film | Charlie's Angels: Full Throttle (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Best International Actress | Shrek 2 (2004) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2005 | N | Favorite Voice from an Animated Movie | Shrek 2 (2004) | - |
| 2004 | N | Favorite Movie Actress | Charlie's Angels: Full Throttle (2003) | - |
| 2002 | N | Favorite Voice from an Animated Movie | Shrek (2001) | - |
| 2001 | N | Favorite Movie Actress | Charlie's Angels (2000) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Supporting Actress | Being John Malkovich (1999) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2014 | N | #WTF Moment | The Counselor (2013) | - |
| 2007 | N | Best Kiss | The Holiday (2006) | Jude Law |
| 2004 | N | Best Dance Sequence (For the burlesque revue) | Charlie's Angels: Full Throttle (2003) | Drew Barrymore, Lucy Liu |
| 2003 | N | Best Kiss | Gangs of New York (2002) | Leonardo DiCaprio |
| 2002 | N | Best On-Screen Team | Shrek (2001) | Eddie Murphy, Mike Myers |
| 2001 | W | Best Dance Sequence (For her fantasy sequence) | Charlie's Angels (2000) | - |
| 2001 | W | Best On-Screen Team | Charlie's Angels (2000) | Drew Barrymore, Lucy Liu |
| 2001 | N | Best Line from a Movie (For "I signed the release, so you can stick anything you want in my slot!") | Charlie's Angels (2000) | - |
| 1999 | W | Best Female Performance | There's Something About Mary (1998) | - |
| 1999 | N | Best On-Screen Duo | There's Something About Mary (1998) | Ben Stiller |
| 1999 | N | Best Comedic Performance | There's Something About Mary (1998) | - |
| 1999 | N | Best Kiss | There's Something About Mary (1998) | Ben Stiller |
| 1998 | N | Best Dance Sequence | A Life Less Ordinary (1997) | Ewan McGregor |
| 1995 | N | Best Breakthrough Performance | The Mask (1994) | - |
| 1995 | N | Best Dance Sequence | The Mask (1994) | Jim Carrey |
| 1995 | N | Most Desirable Female | The Mask (1994) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2004 | N | Best Look (Mejor Look) | Charlie's Angels: Full Throttle (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1998 | W | Best Actress | There's Something About Mary (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | N | Favorite Villain | Annie (2014) | - |
| 2015 | N | Favorite Movie Actress | Annie (2014) | - |
| 2011 | N | Favorite Voice from an Animated Movie | Shrek Forever After (2010) | - |
| 2008 | W | - | - | - |
| 2008 | N | Favorite Voice from an Animated Movie | Shrek the Third (2007) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Best Movie Actress | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2007 | N | Best Kiss (Meilleur baiser) | The Holiday (2006) (TV) | Jude Law |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2000 | N | Best Supporting Actress | Being John Malkovich (1999) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | N | Favorite Comedic Movie Actress | - | - |
| 2013 | N | Favorite Comedic Movie Actress | - | - |
| 2012 | N | Favorite Comedic Movie Actress | - | - |
| 2007 | W | Favorite Leading Lady | - | - |
| 2006 | N | Favorite Leading Lady | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | Best Actress in a Supporting Role | Vanilla Sky (2001) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2015 | W | Worst Actress | The Other Woman (2014), Sex Tape (2014) | - |
| 2015 | N | Worst Supporting Actress | Annie (2014) | - |
| 2015 | N | Worst Screen Combo | Sex Tape (2014) | Jason Segel |
| 2009 | N | Worst Actress | What Happens in Vegas... (2008) | - |
| 2009 | N | Worst Screen Couple | What Happens in Vegas... (2008) | Ashton Kutcher |
| 2004 | N | Worst Actress | Charlie's Angels: Full Throttle (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Best Performance by an Actress in a Motion Picture, Comedy or Musical | Charlie's Angels (2000) | - |
| 2000 | N | Best Performance by an Actress in a Supporting Role, Comedy or Musical | Being John Malkovich (1999) | - |
| 1998 | N | Best Performance by an Actress in a Supporting Role in a Motion Picture - Comedy or Musical | My Best Friend's Wedding (1997) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2002 | N | Outstanding Performance by a Female Actor in a Supporting Role | Vanilla Sky (2001) | - |
| 2000 | N | Outstanding Performance by a Cast in a Theatrical Motion Picture | Being John Malkovich (1999) | Orson Bean, John Cusack, Catherine Keener |
| 2000 | N | Outstanding Performance by a Female Actor in a Supporting Role | Being John Malkovich (1999) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2011 | W | Female Star of the Year | - | - |
| 1996 | W | Female Star of Tomorrow | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2014 | N | Choice Movie Chemistry | The Other Woman (2014) | Leslie Mann, Kate Upton |
| 2014 | N | Choice Movie Actress: Comedy | The Other Woman (2014) | - |
| 2012 | N | Choice Movie Actress: Comedy | "What to Expect When You're Expecting" | - |
| 2011 | W | Choice Movie Actress: Comedy | Bad Teacher (2011) | - |
| 2010 | N | Choice Summer Movie Star: Female | Knight & Day (2010) | - |
| 2008 | N | Choice Movie Actress: Comedy | What Happens in Vegas... (2008) | - |
| 2007 | N | Choice Movie: Hissy Fit | The Holiday (2006) | - |
| 2007 | N | Choice Movie: Hissy Fit | The Holiday (2006) | - |
| 2003 | N | Choice Movie Liplock | Gangs of New York (2002) | Leonardo DiCaprio |
| 2002 | N | Film - Choice Actress, Comedy | The Sweetest Thing (2002) | - |
| 2000 | N | Film - Choice Actress | Being John Malkovich (1999) | - |
| 2000 | N | Film - Choice Hissy Fit | Any Given Sunday (1999) | - |
| 1999 | N | Film - Choice Actress | There's Something About Mary (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | W | Motion Picture (On 22 June; At 6712 Hollywood Blvd.) | - | - |
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