Riggs and Murtaugh are forced to work with DEA agent Karen Palmer (guest star Hilarie Burton) again, to protect Leo Getz (guest star Thomas Lennon), an ambulance-chasing attorney who was linked to the Cartel.
As the three delve further into the case, they begin to realize that Leo may not be the only one with a target on his back. In the meantime, Riggs begins to view Agent Palmer in a new light while Murtaugh is left worried after Trish makes a spontaneous decision.