"God the Worm" centers on Samantha Miller (Annabella Sciorra), a talented singer-songwriter who had a semi-hit record early in her career but nothing since. Now 52 and questioning life's meaning, she is haunted by past choices in love, family and career. In her despair, she asks the universe to give her a sign that she should continue the struggle. What follows is a journey through New York City's colorful neighborhoods where chance encounters with a roster of eccentric and unforgettable characters -- some would call them angels -- help illuminate her path and restore her zeal for life and music.