A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead (Nick Gehlfuss), April (Yaya DaCosta) and her fourth-year medical resident brother Noah (guest star Roland Buck III), who must perform a difficult procedure in the field.
A mother brings in her 8-year-old girl experiencing a sudden hearing loss and Dr. Manning (Torrey DeVitto) is left to tend to the case, which takes a complicated turn. Dr. Choi (Brian Tee) deals with Olga (guest star Betty Buckley), a woman who is malnourished, prompting him to bring in Dr. Charles (Oliver Platt) to help assess the case. Meanwhile, Goodwin (S. Epatha Merkerson) takes measures to get her personal life in order.
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