Two airplane stowaways are brought into the hospital after suffering major injuries from the travel, prompting Sharon Goodwin (S. Epatha Merkerson) to receive a visit from the Department of Homeland Security regarding the undocumented immigrants. Cornelius Rhodes (guest star DW Moffett), the wealthy father of Dr. Connor Rhodes (Colin Donnell), is honored after making a big donation to the hospital for a new psych ward, forcing dark family secrets to the surface. Dr. Natalie Manning's (Torrey De Vitto) big day arrives and Dr. Will Halstead's (Nick Gehlfuss) good intentions to help are misconstrued by her mother-in-law, Helen (guest star Annie Potts). Meanwhile, Dr. Sarah Reese (Rachel DiPillo) asks Dr. Charles (Oliver Platt) for advice on how to deliver heartbreaking news to a young boy while also warning his family about the possibility that their other son may also have the same life-threatening disease.
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