Barry (Bill Hader) is a disillusioned hitman from the Midwest. His handler, Fuches (Stephen Root), sends him to LA to execute a hit for the Chechen mob, led by Goran Pazar (Glenn Fleshler) and his right-hand man, NoHo Hank (Anthony Carrigan).
Barry's target: an aspiring actor who is having an affair with Pazar's wife. Barry follows his "mark" into an acting class taught by beloved teacher/guru Gene Cousineau (Henry Winkler), and is instantly drawn to the group of students, especially Sally (Sarah Goldberg). Barry wants to start a new life in the class, but the criminal world won't let him walk away so easily.