The 32-year-old axed "Don't Matter To Me" from U.K. leg of his "The Assassination Vacation Tour", along with a cover of Jackson's 1979 hit "Rock With You".
"Don't Matter To Me" was released in 2018 and features posthumous vocals from the King of Pop taken from a 1983 demo reel.
Both songs were permanent fixtures in the rapper's "Aubrey & the Three Migos Tour" last year (2018), which he co-headlined with U.S. hip-hop trio Migos, but were noticeably absent from the star's Manchester gig on Sunday, March 10.
The move is thought to have come as a result of the controversial "Leaving Neverland" documentary, which aired in the U.S. and U.K. last week (begin March 3), which features James Safechuck and Wade Robson making a string of allegations of sexual misconduct and abuse against the "Thriller" singer, which reportedly took place when they were young boys.
Representatives for Drake responded "no comment" when contacted by WENN.
The Manchester show was the first of the Canadian rapper's three-night stint in the city, after which he'll head to Dublin's 3Arena and Birmingham's Resorts World Arena for three nights at each venue, before a week-long stint at London's O2 in April.
Following the U.K. leg of the tour, the "Nice for What" hitmaker will head to Las Vegas for the first string of dates of his two-year residency show in XS Nightclub at Wynn Las Vegas.