"Single Ladies" follows new romance and new personal challenges for Raquel (Denise Vasi), April (Charity Shea), Keisha (LisaRaye McCoy), and Omar (Travis Winfrey).

Raquel turns her focus to her boutique, Indulgence, and soon finds passion in an unexpected partnership. April lands the opportunity of a lifetime working for one of Atlanta's most powerful music managers, Felicia Price (LeToya Luckett), who rules her company and the music world with an iron stiletto. While navigating Price Management, April gets embroiled into an ongoing rivalry with her new colleague, David Berenger (Damien Dante Wayans). As Keisha and Malcolm (D.B.Woodside) return to Atlanta from traveling around the world, their relationship is threatened by a sudden tragedy, a mysterious woman, Naomi Cox, (Lesley-Ann Brandt) and other unexpected secrets.

"Single Ladies" is a romantic comedy series about Keisha, Raquel, and April - best friends with different philosophies on love, sex, and relationships - proving that not all women have the same desires. Set in the world of Atlanta fashion, music, and celebrity, Single Ladies asks the question: What do women really want?